++++++++++++++++++++++++++++++++++
++++++++++++++++++++++++++++++++++
+++++++++++++
+++++++++++++
+++++++++++++
+++++++++++++
+++++++++++++
++++++++++++++++++++++++++++++++++
++++++++++++++++++++++++++++++++++
ÍÍÍ THAT'SNEWS
Virus Kills Prostate Cancer
A
R ECO M B I N A NT N E WC A S TLE D I S E A S E
virus (rNDV) targets and kills prostate
cancer cells of all varieties while leaving normal cells unharmed, according
to a multi-institutional study published in the
Journal of Virology.
The oncolytic NDV, which is deadly in chickens
but safe in humans, would allow patients to avoid
the adverse side effects of chemotherapy and
hormonal treatments for prostate cancer. Even
when cancer patients participating in clinical
trials received extremely large doses, only mild
flu-like symptoms resulted.
Although early trials yielded positive outcomes,
the virus failed to reach solid tumors in sufficient
therapeutic concentration. It also spread poorly
within the tumors. Resea rchers have since
modified NDV's fusion protein so it could be
cleaved only by prostate-specific antigen. This
retargeting process enhanced
both the effectiveness and efficiency of NDV in destroying
prostate cancer cells, including
hormone-resistant cells.
Prostate cancer is the second
leading cause of cancer-related
deaths in the United States.
Approximately one in six men
will be diagnosed with prostate
ca ncer, a nd one in 36 will die
of it. I
A DV E R T I S E R S ' I N D E X
Keurig.................................... Inside Front Cover
Knopf Audi ..........................................................22
Mayo Clinic ........................................ Back Cover
WE'D LIKE TO HEAR FROM YOU!
At MD News, we strive to give you
superior, relevant content in every issue.
To ensure we're delivering value, please
take three minutes to complete a survey
at www.mdnews.com/survey. Tell us
what you think of the magazine, and
we'll enter you in a drawing to win
an iPad Mini.
