MDNews - Central Pennsylvania

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ Contents JULY/AUG/SEPT 2013 6 PAGE ON THE COVER OSS Orthopaedic Hospital: Focusing on Patient Satisfaction, Excellent Outcomes FEATURES DEPARTMENTS AWARD-WINNING WOUND CARE FROM HEART OF LANCASTER REGIONAL MEDICAL CENTER 5 With a 95 percent wound-healing rate, compared with a 92 percent national average, the Wound Healing Center of Heart of Lancaster Regional Medical Center is the logical choice for referral of patients with nonhealing wounds. ORTHOPEDICS ONCOLOGY OB/GYN SPOTLIGHT IN THE NEWS 12 16 17 18 OSS ORTHOPAEDIC HOSPITAL: FOCUSING ON PATIENT SATISFACTION, EXCELLENT OUTCOMES 6 Providers at OSS Orthopaedic Hospital keep patient satisfaction at the forefront in CLINICAL FEATURE delivering comprehensive, accessible and, whenever possible, minimally invasive musculoskeletal care to residents of York County and surrounding areas. A PRECISE APPROACH TO FULL AND PARTIAL JOINT REPLACEMENT AT CARLISLE REGIONAL MEDICAL CENTER 8 At Carlisle Regional Medical Center, surgeons utilize MAKOplasty to perform customized total hip and partial knee replacements. This procedure generates numerous benefits for patients. p o "T o sc th 10 ZEROING IN ON EFFECTIVE TREATMENTS FOR RETICULAR AND SPIDER VEINS 9 Calcagno & Rossi Vein Treatment Center physicians discuss the best approaches for treating reticular and spider veins. M THE FUTURE in a Dish SPECIAL CLINICAL FEATURE: THE FUTURE IN A DISH 10 Scientists expect major breakthroughs in tissue replacement and pharmaceutical testing thanks to research by Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., who discovered human adult cells could be reprogrammed to mimic embryonic stem cells. Already, researchers have engineered cartilage and bone in mouse and pig models. SPECIAL CLINICAL FEATURE: TRACING THE LINK BETWEEN MENOPAUSE AND COGNITION 14 Recent studies indicate the negative changes in cognitive functioning following surgical or natural menopause are neither frivolous nor merely a natural part of aging. Rather, they are real physiological responses to the reproductive transition. BUILDING UPON NOBEL PRIZE AWARD-WINNING RESEARCH, SCIENTISTS STAND ON THE VERGE OF MONUMENTAL BREAKTHROUGHS IN TISSUE REPLACEMENT AND PHARMACEUTICAL TESTING. IN 2007, SHINYA YAMANAKA, M.D., Ph.D., senior investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation investigator in stem cell biology and professor of anatomy at the University of California, San Francisco, discovered human adult cells could be reprogrammed to mimic embryonic stem cells. Dr. Yamanaka dubbed these "induced pluripotent stem" (iPS) cells, and although extensive research into iPS cells' therapeutic and pharmaceutical use has not advanced past animal studies, researchers have successfully engineered cartilage and bone in mouse and pig models. The primary benefit of iPS cells is researchers can create any kind of tissue from a single cell, according to Farshid Guilak, Ph.D., professor of orthopedic surgery at Duke University Medical Center. Using mice, Dr. Guilak's team successfully engineered cartilage harvested from adipose cells. To encourage the cells to turn into 6 cartilage, Dr. Guilak's team replicated the anatomical environment in which cells typically differentiate in the body by exposing them to transforming growth factor and bone morphogenetic proteins. Using known sequences of growth factors involved in cartilage a nd bone formation, Dr. Guila k 's team found the growth factor — bone morphogenetic protein 4 — responsible for turning on genetic expression for cartilage. Using these methods, Dr. Guilak and his colleagues have produced the best cartilage he's ever seen in a petri dish, which is where immediate clinical applications may be observed. Engineered cartilage likely won't be approved for transplantation for some time, but the patient-specific tissues present in the lab provide immediate opportunity for medical breakthroughs. "One thing we can readily do now is develop a series of stem cells from different patients to make unlimited supplies of cartilage or other tissues matched to a P B ca fo F A en d th te T fu m b h si th lo as o im b m (C sc w sc fr ca

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