MDNews - San Antonio

A P OS SIBLE NE W means of treating an advanced form of prostate cancer disrupts the primary way the cancer cells grow and spread, according to the National Cancer Institute (NCI). Androgen receptor activity is the most common means by which prostate cancer cells spread. In order to disrupt that activity, researchers treated prostate cancer cell lines and animal models with molecules that target a nuclear receptor protein, ROR-γ, which is believed to regulate the androgen receptor gene. The focus of the research was androgen-independent or castration-resistant prostate cancer. "In mouse models of castration-resistant disease, treatment with ROR-γ inhibitors led to substantial and prolonged shrinkage of tumors, and in mice with tumors that had been resistant to the AR-targeted therapy enzalutamide (Xtandi), the treatment appeared to restore their sensitivity to the drug," the NCI reported. The findings appeared in Nature Medicine. ■ ƒ By Steve Barrett A Promising Approach to Fighting Prostate Cancer activity, researchers treated prostate cancer cell lines and animal models with molecules that target a nuclear receptor protein, 2 3 M D N E W S . C O M /// M D N E W S S A N A N T O N I O ■ 2 016 THE NIGHTMARE SCENARIO FOR A PHYSICIAN SEEKING SOUND FINANCIAL COUNSEL IS THAT HE OR SHE SELECTS AN ADVISER WHO IS DISHONEST OR INCOMPETENT. BUT IT IS ALSO PERILOUS TO CHOOSE A PERFECTLY HONEST ADVISER WHO IS COMPETENT IN THE ABSTRACT BUT L ACKS AN UNDERSTANDING OF PHYSICIANŸSPECIFIC INVESTMENT NEEDS. Advice on Advisers BY STEVE BARRETT FOR EX AMPLE, FOR many physicians it is vita l to ensure that a potentia l adviser has an understanding of medica l student debt, Robin Rober tson, a Senior Wea lth Adviser for Tennessee-based Millennium Brokerage Group, tells AMA Wire, an online publication of the AMA. An adviser should be readily able to discuss whether a physi- cian should pay o… his or her loans early on, as well as other loan repayment strategies. Questions about disability a lso fi g ure la rge in physicia ns' fi na ncia l pla nning. Advisers should be able to help physicians fi nd "the Cadillac of disability policies," Robertson tells A MA Wire, because their ability to earn a living is inextricably bound to their ability to work. Ne wer phy s ic i a n s s hou ld c on s ider pa r t ner i n g w it h a dv i sers of a si m i la r age, she adds. A young certifi ed fi nancia l planner will have a minimum four years of experience but will still be a … ordable. Plu s , you n ger a dv i ser s a re w i l l i n g t o accept new clients, and the physician and adviser ca n form a solid relationship as their careers progress. ■

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