Issue link: https://viewer.e-digitaledition.com/i/140431
Virus Kills Prostate Cancer A RECOMBINANT NEWCASTLE DISEASE virus (rNDV) targets and kills prostate cancer cells of all varieties while leaving normal cells unharmed, according to a multi-institutional study published in the Journal of Virology. The oncolytic NDV, which is deadly in chickens but safe in humans, would allow patients to avoid the adverse side effects of chemotherapy and hormonal treatments for prostate cancer. Even when cancer patients participating in clinical trials received extremely large doses, only mild flu-like symptoms resulted. Although early trials yielded positive outcomes, the virus failed to reach solid tumors in sufficient therapeutic concentration. It also spread poorly within the tumors. Researchers have since modified NDV's fusion protein so it could be cleaved only by prostate-specific antigen. This retargeting process enhanced both the effectiveness and efficiency of NDV in destroying prostate cancer cells, including hormone-resistant cells. Prostate cancer is the second leading cause of cancer-related deaths in the United States. Approximately one in six men will be diagnosed with prostate cancer, and one in 36 will die of it. I A DV E R T I S E R S ' I N D E X Atlantic Management ....................................................14 Cushman & Wakefield Healthcare .............................15 Keurig....................................................................................5 Signature Healthcare ...................................Back Cover Southcoast Health System...........Inside Front Cover Winchester Hospital....................................................... 13 Wound Care Experts In Your Community Winchester Hospital's Wound Healing and Hyperbaric Center offers: • Multidisciplinary,casemanagementapproachtomanagingacute, chronicornon-healingwoundscausedbydiabetes, circulatoryproblemsandotherconditions • Personalized,state-of-the-artwoundtreatment programsforeachpatient,includinghyperbaric oxygentherapy • Expertwoundcareinyourcommunityfor morethanadecade To make an appointment with one of our wound care experts, call 781-396-8224