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ThAT'SNEWS
Early Huntington's Disease
symptoms Prevented
R
University in Sweden report they have
found a way to prevent early emotional symptoms of Huntington's
disease (HD) in BACHD mice by inactivating the mutated
huntingtin protein in the hypothalamus.
While previous research has focused on physical symptoms of HD — such
as uncontrollable movement, which occurs later in disease progression —
this study's success in hampering the emotional effects of HD suggest
addressing the dysfunctional hypothalamus in patients with HD could
have a significant effect on the disease's early development. The results
also point to a possible connection between other depressive conditions
and similar protein mutations.
The study's authors say further research of the hypothalamus' role
in HD could lead to treatments that target specific nerve cells in
the hypothalamus. ■
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