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+++++++++++++++++++++++++++++++++++ +++++++++++++++++++++++++++++++++++ ++++++++++++++ ++++++++++++++ ++++++++++++++ ++++++++++++++ ++++++++++++++ +++++++++++++++++++++++++++++++++++ THAT'SNEWS The Metabolic Answer to Chemotherapy Resistance RESEARCHERS AT THE Kimmel Cancer Center at Jef ferson have, in studying the metabolic basis of cancer cell resistance, discovered a successful combination of two chemotherapy drugs to treat hormone refractory breast cancer. While 70% of all breast cancers are char- acterized as estrogen receptor positive, up to 35% initially present hormone resistance or will develop an immunity over the course of treatment, specifi cally to the widely used drug tamoxifen. However, when tamoxifen was paired with dasatinib, a chemotherapy agent used to treat leukemia, the researchers observed an increase in cancer cell death of 80%. The study, published in Cell Cycle, detailed its fi ndings related to the metabolic process of both chemotherapy resistance and how the double dose broke the cancer cell growth. Through oxidative stress, cancer cells trigger fi broblasts to supply the nutrients needed for rapid proliferation. Neither dasatinib nor tamoxifen demonstrated effectiveness when used alone, but when coupled, the drugs regularized fi broblasts' glucose intake, thus decelerating the oxidative stress process and interrupting the cancer cells' fuel. s Expanding the Range of Microscopic IMAGING BUILDING ON THE success in the field of ophthalmology at monitoring glaucoma, endoscopic optical coherence tomography (OCT) is finding application in imaging the pre-cancerous changes of esophagus and colon cancer cases. The OCT technology eclipses standard endoscope imaging in its ability to see tissue both structurally and pathologically at a microscopic level — as small as a few millionths of a meter — three dimensionally. Its speed also recommends the technology for esophagus and colon cancer: OCT images at 980 frames per second, which equals 480,000 axial scans in real time. Rather than employing sound waves to create a picture of the body's anatomy, the technology utilizes a system of directing a light beam at a tissue structure and tracking the intensity and echo time-delay of the light as it is backscattered. Developers at the Massachusetts Institute of Technology say the device must be reduced in size for insertion in the colon or throat before being introduced for general use. s ADVERTISERS' INDEX First Consult................................................. 11 Goodell Stratton Edmonds & Palmer, LLP ....Back Cover Kansas Pathology Consultants P.A. ...... Inside Back Cover Via Christi Health ...... Inside Front Cover Wichita Nephrology Group, P.A. ......... 14 14 | Greater Kansas MD NEWS MDNEWS.COM