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Multiple Services With A Single Focus: Your Success © Copyright 2015. CBIZ, Inc. NYSE Listed: CBZ. All rights reserved. 4040 Embassy Parkway, Suite 100 • Akron, OH 44333 Martha Bethea 330.668.6500 • www.cbiz.com n Efciency reengineering n Financing structure and negotiations n Reimbursement methodologies – risk sharing – bundle payment n Structure for related businesses n Medical practice merger, acquisition, integration n Financial statement preparation and analysis A CLE VEL AND CLINIC RESE ARCH TE AM HA S DEMONSTR ATED THAT AN ENZ YME CALLED ARGINA SE RE VS UP CELLUL AR ME TABOLISM IN A STHMA, A FINDING THAT SHEDS NE W LIGHT ON THE BIOLOGICAL SIMIL ARITIES BE T WEEN A STHMA AND OBESIT Y WHILE ALSO SUGGESTING POTENTIAL NE W TRE ATMENT STR ATEGIES. L E D B Y S E R P I L E R Z U R U M , M D , a pu lmonolog i s t who i s C h a i r of t he Depa r t ment of Pat hobiolog y at t he Lerner Research Institute at Cleveland Clinic, the resea rch tea m found that t he process of energ y production — known as cellular respiration or aerobic metabolism — occurs to a greater degree than norma l in the presence of asthma. This metabolic increase is caused by cha nges in a mitochondria l enz y me ca lled arginase. Using a mouse model of asthma, they showed that a rg ina se activation a nd availability is enhanced, a llowing the cel ls to produce more energ y during cellular respiration. Interestingly, they fou nd t hat t he i ncrea se i n met abo - lism suppressed infla mmation in the lungs a nd protected a sthmatic mice from developing more severe forms of the disease. "Our results indicate that enhanced a rginine metabolism may counteract infla mmation a nd possibly o¥er pro- tection for a sthmatic patients," says Dr. Erzurum. "It also supports mounting evidence that bioenergetic changes and inf la mmation underlie both a sthma and obesity." Asthma and obesity have long been associated with each other, but a definitive biological link between the diseases has not yet been discovered. More studies are needed to clarify the exact mechanisms of arginase upregulation. About 22 million Americans su¥er from asthma, which causes wheezing, coughing and shortness of breath and in some cases can lead to death. Exercise, allergies and airborne dust can set o¥ asthma attacks. The study's findings are published in the current issue of The Journal of Clinical Investigation: http://www.jci.org/arti cles/view/82925. ■ Link Between Asthma and Metabolism STUDY SHOWS M D N E W S . C O M /// M D N E W S C L E V E L A N D /A K R O N / C A N T O N n J U LY/A U G U S T 2 016 1 5 R E C E N T R E S E A R C H 1 5